|
KMID : 0374019790020030161
|
|
Ewha Medical Journal
1979 Volume.2 No. 3 p.161 ~ p.164
|
|
|
Influence of Diazepam, Cimetidine and Sulpiride on the Level of Hepatic Microsomal Cytochrome P-450 in Rats
|
|
|
|
|
Abstract
|
|
|
Cytochrome P-450 is a terminal oxidase of the hepatic microsomal monooxygenase system associated with the oxidative biotransformation of a varity of lipophilic endogenous and exogenous compounds, and generally is assayed by CO-binding spectro-photometry of dithionite-reduced samples.
In well-fed normal male rats with or without stress condition, the effect of antiulcerdurg; cimetidine, sulpiride and diazepam on the level of microsomal cytochrome P-450 were determined. Only stress condition produced no significant effect in cytochrome P-450 contents. Administration of cimetidine, sulpiride and diazepam in this condition caused a 44.1%~87.5% increment in cytochrome P-450, diazepam produced the most increase. After diazepam treatment of rats, the peak position of cytochrome P-450 shifited to a longer wave length of 452 nm.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|